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Ouray is located in the Southwest corner of the beautiful state of Colorado just west of the midwest portion of the USA.
From Denver, take US 285 South past Fairplay to Poncha Springs which is near Salida. Head West on US 50 through Gunnison to Montrose. Head South on US 550 to Ouray.
From Grand Junction, you'd head South on US 50 to Montrose and go from there.
From Durango, you'll simply want to point North on US 550 until you head into Ouray.
If you're heading in from Albuquerque, head up I-25 to Walsenberg, head West on US 160 to Durango. Alternatively, if you can find your way to US 285, head into Alamosa, then follow 160 to Durango.
Here's a collection of tool that provide you with weather reports, fuel prices, route planning, road conditions and construction, and more!
Colorado Road Conditions,
Weather, Etc. by CDOT 
Map
of Colorado fires and their status